منابع مشابه
Equipoise and the technology curve
520 Freely available online open Access bJr bJr elimination of bias is a core element of high quality clinical trials. 1 In addition to selection, detection, attrition, reporting and spectrum bias, 2 a further type of bias has been reported, known as 'design bias'. 3 this occurs before the trial is begun and is inconsistent with the principle of 'equipoise' and has relevance for surgical trials...
متن کاملEquipoise and the criteria for reasonable action.
441 In her recent article, “Evidence, Belief, and Action: The Failure of Equipoise to Resolve the Ethical Tension in the Randomized Clinical Trial,” Deborah Hellman gives a new twist to an old objection against clinical equipoise.1 Roughly, clinical equipoise is the requirement that there exist credible uncertainty in the expert medical community regarding the preferred treatment for a particul...
متن کاملGlycemic equipoise
The term “equipoise,” defined as “a state of equilibrium,” is a noun as well as a verb.[1] Clinical (or community) equipoise, which implies that there is uncertainty among the medical fraternity regarding the benefit, or otherwise, of a clinical intervention, provides the basis for conducting clinical trials.[2] Equipoise is also used as a guiding tool for patient–physician interactions, which ...
متن کاملEquipoise and the ethics of clinical research.
The ethics of clinical research requires equipoise--a state of genuine uncertainty on the part of the clinical investigator regarding the comparative therapeutic merits of each arm in a trial. Should the investigator discover that one treatment is of superior therapeutic merit, he or she is ethically obliged to offer that treatment. The current understanding of this requirement, which entails t...
متن کاملCorrealism and Equipoise: Observations on the Sustainable
Modern environmentalism originates with the recognition of ecological connectivity and the negative effects of technological intervention. This paper examines critical concepts developed by the architect Frederick Kiesler and the critic-historian Siegfried Giedion for their relevance to that discourse. Kiesler’s principle of Correalism and Gieidon’s appeal for Equipoise offer both a prehistory ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2016
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dew286